GABAB receptor modulation of synaptic function
نویسندگان
چکیده
منابع مشابه
Effects of mu-opioid receptor modulation on GABAB receptor synaptic function in hippocampal CA1.
Activation of mu-opioid receptors (MORs) alters information coding, synaptic plasticity, and spatial memory in hippocampal CA1. In CA1, MORs act by inhibiting GABA release onto both GABA(A) and GABA(B) receptors exclusively. MOR activation can facilitate excitatory inputs in CA1 dendritic layers by inhibiting synaptic activation of GABA(A) receptors. In this study, we use voltage-sensitive dye ...
متن کاملEffects of -Opioid Receptor Modulation on GABAB Receptor Synaptic Function in Hippocampal CA1
McQuiston AR. Effects of -opioid receptor modulation on GABAB receptor synaptic function in hippocampal CA1. J Neurophysiol 97: 2301–2311, 2007. First published January 10, 2007; doi:10.1152/jn.01179.2006. Activation of -opioid receptors (MORs) alters information coding, synaptic plasticity, and spatial memory in hippocampal CA1. In CA1, MORs act by inhibiting GABA release onto both GABAA and G...
متن کاملDifferential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neurons.
We tested the hypothesis that differential sensitivity to ethanol of synaptic GABA(A) somatic and dendritic inhibitory postsynaptic currents (IPSCs) in hippocampal CA1 pyramidal neurons could be due to differences in the extent of GABA(B) receptor activity at GABAergic synapses in these two hippocampal subfields. Our present results show that dendritic (distally evoked) GABA IPSCs contain a lar...
متن کاملAstrocytes as gatekeepers of GABAB receptor function.
The long-lasting actions of the inhibitory neurotransmitter GABA result from the activation of metabotropic GABA(B) receptors. Enhanced GABA(B)-mediated IPSCs are critical for the generation of generalized thalamocortical seizures. Here, we demonstrate that GABA(B)-mediated IPSCs recorded in the thalamus are primarily defined by GABA diffusion and activation of distal extrasynaptic receptors po...
متن کاملIntron 4 Containing Novel GABAB1 Isoforms Impair GABAB Receptor Function
BACKGROUND Gamma-aminobutyric acid type B (GABAB) receptors decrease neural activity through G protein signaling. There are two subunits, GABAB1 and GABAB2. Alternative splicing provides GABAB1 with structural and functional diversity. cDNA microarrays showed strong signals from human brain RNA using GABAB1 intron 4 region probes. Therefore, we predicted the existence of novel splice variants. ...
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ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2011
ISSN: 0959-4388
DOI: 10.1016/j.conb.2011.02.004